Science

I'm currently developing T-Cell Engagers for solid tumors.  They are "eat me" signals that attach to cancer cells kill them.  It is a very simple concept but can easily kill someone if they bind to normal cells.

We make T-Cell Engagers that are inactive until they get to the tumor, reducing toxicity.

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Ask me any questions you want about what we're doing!

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This is awesome research.  Thank you for doing the research you are doing!

Thanks!  Yes this is for solid tumors, there are already good immunotherapy treatments for liquid tumors.

The algorithm hid your casts so i just checked in and saw this cast. This is super cool science!  Will this only work on solid tumours? 

Also this is the last of my allowance and I wanted you to have it. 

You have been so supportive! 

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It’s a bispecific ScFv (small antibody that attaches to two things).  

One side binds to the tumor and the other side calls in T-Cells.  

We keep specificity because the drug is actually inactive until it gets to the tumor microenvironment where it binds and then gets activated by proteases on the tumor.

How is this different from antibodies? How do you determine specificity of tumor vs healthy?

Very cool, similar concept but CART requires a lot of engineering, I was super excited about allogenic CART’s but they haven’t done much in solid tumors so far.  

T Cell Engagers appear to be working so far  🤞

Pretty cool my wife is working on using NK version of CART because CART can be risky where you need T donors or your own T cells because of graft vs host

Would this treatment be effective for all stage of cancer or would it be less effective once you reach a certain stage? Both my parents found they had cancer at stage 4 and it was too late for most treatments to be effective for them and they passed away. Hence my interest in cancer treatments.

Almost all solid tumors, just need to have the target expressed on the tumor cell surface

Would this kind of treatment be viable for all kind of cancers or more suited for just some kind of cancers?

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so cool! Wait if not activated what is the half-life? Could this be given in anticipation of a tumor formation?

We’re still working on question one…for now we use broad protease activated linkers but that’s actually what I’m working on. 

Seems to work on any solid tumor where the target is expressed on the cell surface.  

Once activated the half-life is short (safety benefit) but once T Cells are doing their thing there is kind of a chain reaction.  Not quite sure how it all works

OOH I have some questions:
Do all tumor types produce the right proteases necessary to activate the T-Cell engager?

Are there any tumorigenic cancers this can't work on for other reasons? 

How long do they linger in the body? Can they be recycled after the tumor dies and attach to a new tumor?

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I’ve had interest in all things cancer after my wife had it

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My brother that's a middle school science teacher would think this is interesting

/science is pretty cool!  

We’re using the immune system to kill cancer

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follow up, how do they know when they’ve found the tumor?

IV injection, they just go through the body until they find the tumor and the half targeting the tumor binds to it!

Very cool.

Now do they get to the tumor?

💻🐒

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thank you for doing what you do! 
is this treatment effective for all types of cancer , or just a few for now?

Still in clinical trials.

Great question, proteases involved in cancer progression activate the drug, without those proteases and cancer cells it is inactive.

how do you ensure that the t cell engagers remain inactive until they reach target? is this type of treatment available to everyone, or is it still being tested?

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It really is!  Utilizing the existing t-cell in your body to kill cancer

not me actually understanding this. bring a med student is kinda cool ngl 😎