Science

I'm currently developing T-Cell Engagers for solid tumors.  They are "eat me" signals that attach to cancer cells kill them.  It is a very simple concept but can easily kill someone if they bind to normal cells.

We make T-Cell Engagers that are inactive until they get to the tumor, reducing toxicity.

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How is this different from antibodies? How do you determine specificity of tumor vs healthy?

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It’s a bispecific ScFv (small antibody that attaches to two things).  

One side binds to the tumor and the other side calls in T-Cells.  

We keep specificity because the drug is actually inactive until it gets to the tumor microenvironment where it binds and then gets activated by proteases on the tumor.