For example. With above 100% tariffs on China, China will start dumping its excess inventory in South America. From there they will start getting smuggled into USA. The higher the tariff, the more lucrative smuggling becomes.
But smugglers are usually criminals. So when criminals start making big bucks, crime goes up. I will bet you a $1000 that you will see Fentanyl rise up within the next year.
This is not conjecture, these patterns are as solid as any laws of nature.

Keep thinking about cascading effects. 
- All drop shipping: dead
- IoT startups that design PCBs and get them mass printed from China: dead
- A huge number of Kickstarter projects: dead

Some subset will ultimately refocus on customers outside of the US.

Maybe the real American Privilege was always being the first target market. Kinda how for a long time, most mobile apps were iOS-first.