Science

“NIH will no longer seek proposals exclusively for animal models.”

Love to see it.

“NIH will no longer seek proposals exclusively for animal models.”

Love to see it.

https://www.drugdiscoverytrends.com/nih-announces-end-to-funding-for-animal-only-studies/

Meridian Radiopharmaceuticals
https://www.meridianradiopharmaceuticals.com/

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It's really here and there. Organs on a chip are cool but they don't account for systemic effects of new agents. 

There's a lot of nuance to all of this, I think we should allow people to opt into studies versus compromising with stuff like this.

Legitimately just always start with dose escalation to minimize potential issues

For sure, my argument is that we should be able to test in humans, directly.

At SNMMI there was a series of talks lampooning the boondoggle that are murine models.

Phase 1 trials are dose escalation, anyhow - we should be able to conjugate new drugs with radiotracers and administer the tiniest dose to at least get ADME/PK.

We need actions like this to encourage the development of organoid technologies. Biotechs and pharma are very risk adverse, and even small steps like this do get them to look at them.