Science

I'm currently developing T-Cell Engagers for solid tumors.  They are "eat me" signals that attach to cancer cells kill them.  It is a very simple concept but can easily kill someone if they bind to normal cells.

We make T-Cell Engagers that are inactive until they get to the tumor, reducing toxicity.

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OOH I have some questions:
Do all tumor types produce the right proteases necessary to activate the T-Cell engager?

Are there any tumorigenic cancers this can't work on for other reasons? 

How long do they linger in the body? Can they be recycled after the tumor dies and attach to a new tumor?

microbiology PhD | fiber artist | synbio | scicomm | really into extremophiles

We’re still working on question one…for now we use broad protease activated linkers but that’s actually what I’m working on. 

Seems to work on any solid tumor where the target is expressed on the cell surface.  

Once activated the half-life is short (safety benefit) but once T Cells are doing their thing there is kind of a chain reaction.  Not quite sure how it all works

so cool! Wait if not activated what is the half-life? Could this be given in anticipation of a tumor formation?

Half life is about a week when not activated.  Wouldn’t be preemptively taken or anything