@icetoad.eth
On today's date in 1943, Albert Hofmann accidently dosed himself with LSD. This was the first ever consumption, accidental or not, of this novel psychedelic.
Hoffman was investigating organic compounds derived from ergot fungus, a rye crop pest. Specifically, when he synthesized LSD, he was trying to synthesize a respiratory and circulatory stimulant. This initial synthesis didn’t yield any huge breakthroughs, though, and he all but set the molecule aside. When he came back to it 5 years later and got a small amount of it on his skin this is how he described it:
“Last Friday, April 16, 1943, I was forced to interrupt my work in the laboratory in the middle of the afternoon and proceed home, being affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant, intoxicated-like condition characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away."
Once he realized the drug’s potential, Hoffman’s next step was intentionally ingesting it 3 days later. He estimated that a threshold dose, just enough to feel the drug, was about 250 micrograms. He was way off, though, as a threshold dose of LSD is closer to 20 micrograms. Quite abruptly, he was deep in the otherworldly realm of the LSD experience. In the midst of this new experience, Hoffman had to ride his bicycle home because World War II was raging through Europe, so motor vehicle usage was restricted. After some initial paranoia, and even a visit from his doctor, Hoffman settled into his first full on trip in the comfort of his home.
A GOAT is there ever was one!