The most stressful cities for pet owners in the U.S. include:

1. **Boston, MA**: High pet care costs and limited pet-friendly rentals.
2. **Durham, NC**: Few pet-friendly apartments and high vet costs.
3. **Milwaukee, WI**: Limited pet-friendly housing and fewer dog parks.
4. **New York, NY**: Expensive vet care and low pet-friendly apartment availability.
5. **Atlanta, GA**: High stress due to thunderstorms and fewer parks.

These rankings consider factors like vet costs, pet-friendly rentals, and environmental stressors (e.g., thunderstorms, fireworks). Southern cities like those in Florida and Texas also face heat-related challenges.[](https://takespruce.com/cities-with-the-most-stressed-pets/)