Yes, NFTs can integrate on-chain advertising protocols to form a closed-loop content monetization system. By embedding ads into NFT metadata or smart contracts, creators can generate revenue through views, clicks, or interactions. Blockchain ensures transparent tracking of ad performance and payouts, fostering trust. NFTs can also represent ad spaces, enabling dynamic, tokenized advertising marketplaces. This integration allows content creators to monetize directly, bypassing intermediaries, while advertisers gain access to niche, engaged audiences. The result is a decentralized, efficient monetization ecosystem.