Jeffrey Koury

@jeffreykoury

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76 Followers

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Curious if you’ve heard about ResearchHub, we’re incentivizing peer review of preprints with crypto: https://www.researchhub.com/trending Also taking on crowdfunding of scientific research!

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ResearchHub Foundation

How Crowdfunding Works on ResearchHub. ResearchHub is giving donors and researchers more control by offering a faster and more transparent way to fund science. How it works: 1. Preregister the experiment Researchers publish their full methodology and planned analyses before asking for funding. This supports transparency and reproducibility. 2. Get expert peer review The community provides early feedback, improving scientific rigor before any money is raised. 3. Link to a nonprofit (optional) To unlock tax-deductible giving, researchers can link their project to a qualified nonprofit (e.g. a university foundation). Donations to the project greater than $500 become eligible for tax exemption. 1/2 https://farcaster.xyz/researchhubf/0xd5b49a4d

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ResearchHub Foundation

What’s new in ResearchHub v2?

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new.researchhub.com/fund

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We’ve had $500K in crypto flow into research on mainly psychedelics and breathwork. Plenty more topics popping up. If you want to allocate tax-deductible crypto to specific scientific projects take a look at ResearchHub

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Would love any help with amplifying this. It's a huge feature for Bountycaster! :) https://x.com/ljxie/status/1809339166838145424?s=46&t=QNlz9swNdb9dxGQvZZJaCw

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ResearchHub is looking to integrate ResearchCoin ($RSC) on Base to our platforms deposit/withdrawal flow + would love help integrating Smart Wallets & paymaster. Any open source devs out there looking to help accelerate the pace of scientific research & earn $RSC for the work please DM me 🫡 https://www.researchhub.com/

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Advantage Blockchain🔵

fresh out the laboratory, Research Hub is revolutionizing the entire open science industry @jeffreykoury & @researchhubf 🧬🧪👩‍🔬💐 https://www.youtube.com/watch?v=8S0CvZ5krKE

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Feels it may have too many case by case complexities. General commentary on hypothesis driven research, it does sometimes tend to drive researchers into shoehorning data to fit their narrative 🤔

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100%. Emailing each other word docs with track changes can’t be the end state. We’re also tackling this with an organization capable lab notebook on RH, which you use to publish directly to the feed. Fractionalized NFTs for authorship feels like a good move too: % contribution = % ownership of NFT

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ResearchHub has actually been experimenting with crowdfunding pre-registrations. Preregistrations have been shown to intrinsically improve reproducibility due to the transparency of the methodology up front. https://www.researchhub.com/funding

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I think publishing. However, there’s a largely cultural hurdle to overcome here. Publishing in high impact journals gives you the stamp of credibility to receive more funding and move up the career ladder. Best way to fix publishing might be to also fix funding. A one two punch.

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My 2 cents is reputation (when weighted with the correct parameters) is a good way to add context. The issue now is reputation is mostly monovariate (citations). Web2 platforms actually had reputation scores, but they failed largely to their inability to be ported off each respective platform. Web3 = portable 🫡

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The infrastructural changes these people made, and are making, to science will improve the pace of science information dissemination, and subsequently therapeutic discoveries. This is a stepwise improvement to ALL of science, but because it’s fixing the backend of science, others often get more attention.

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Richard Sever and John Inglis for spearheading biorxiv, and Michael Eisen for the progressiveness of eLife. Just like how tax is silent theft of our money, the traditional publishing system is silent theft of our scientific time.

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Blockchains are public ledgers with intrinsic consensus mechanisms. The ideal tool for fixing publishing hidden behind paywalls with no good mechanism of finding “truth”. I joined RH Foundation 2 yrs ago because the product was being built, the team was pragmatic, and most importantly the culture was 💯

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I’ve been entrenched in the academic infrastructure for over a decade. Big universities, small universities, basic sciences, clinical trials, grant writing, publishing etc. Lived through pain points. After my foyer into crypto in 2017, it took me embarrassingly 4 years before thinking of a similar concept to RH.

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Actually, the lion-share of interactions have been positive. The legacy publishers are well aware of what’s going on in the DeSci space. I must say, the most resounding “👍” from traditional academic PIs/Staff has been around financially incentivized peer review

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post-cART era, HAND wasn’t progressive (can check out a longitudinal study called CHARTER). Before cART it was progressive, and so the quicker one receives treatment the better. In fact, it takes about 1-2 weeks for detectable virus to make its way into brain/CSF, so catching it before that would be the most ideal.

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Great question. combination antiretroviral therapy (cART) can drop viral load to undetectable levels, however overall prevalence of HAND is unchanged. Albeit, we see more of the milder forms, and less of the severe forms. Can see Saylor et al 2016, Fig 2 for a nice schematic: https://pubmed.ncbi.nlm.nih.gov/26965674/

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