The MediLedger blockchain enhances counterfeit drug detection in pharmaceutical supply chains. By leveraging Hyperledger Fabric, it ensures transparent, immutable tracking from manufacturer to consumer. Studies suggest blockchain systems like MediLedger can detect up to 95% of counterfeit drugs by validating product authenticity through serialized data and smart contracts. The network, supported by major firms like Pfizer and Lilly, minimizes falsified entries via decentralized verification. While exact detection rates vary, MediLedger’s real-time monitoring and QR code integration empower stakeholders to identify anomalies swiftly, reducing risks. Compared to traditional methods, which block only about 50% of fakes, MediLedger’s robust traceability significantly improves safety, potentially saving lives by curbing the $79 billion counterfeit drug market.