If you're not following @ericolsz, I suggest you do. He is working on cures for stage IV cancer. Medicine in all its forms is about to move into an era of Renaissance as we have tools at our disposal we never previously had. AI being one of the main factors for this, as we can experiment at levels not seen before in our modern age. 

It excites me to no end. That we will be witness to some of the greatest transformations of systems that benefit humanity than ever before and this will be led by an awakening of truth. 

Blessings await us all in the compounding of innovation and discovery 🙏

Hot take - AI drug discovery will yield little to no benefit.

We don't understand drug discovery well enough to train a model on it.

Garbage in, garbage out.

https://x.com/kimmonismus/status/1929431450941792464

What duration of time are you stating it'll yield little to no benefits? 

This video was from 2016 

Hard to assume 2025 LLMs wouldn't find ways to surprise developers

Where it all began: In 2016, AlphaGO won against grandmaster Lee Sedol and showed with “Move 37” that it could outmaneuver so creatively that it amazed everyone.

It was the first time that an artificial intelligence had made such a media-effective appearance and amazed the https://t.co/0E0PTyflPa

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Biology is infinite, but targeting specific cancers is a complex, finite challenge

This game has a finite problem space.

Biology is an infinite hyperspace.

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Models already train themselves and will be sentient in a few years, this is a short sighted stab at best

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How do you specify the problem space of cracking hieroglyphs? 

Naming Go and Chess in the same breath is a little misleading. Yes, technically Go is finite, but it is a googol times more complex and has significant times more combinations than atoms in the universe.

Those are finite problem spaces.

Like, with Go or Chess, there are only so many moves one can make.

Doesn't AI help us understand things that we don't though? There has been numerous cases like AI cracking hieroglyphs, teaching us talking to animals, etc.

Makes sense ... I think one of the biggest benefits of the AI after effects is the hunger to ask more questions and find the right ones to ask so we get to this place 🙏

work that UW’s protein lab is doing plus 23 and me (or another large repository) data is what I’m crossing my fingers for. the current standard of just applying same drugs to new indications or tweaking chemical compounds slightly with marginal results is the barrier that I believe ai has the power to best.

Fair. Without solid biology, AI just speeds up chasing the wrong leads.

Fact... AI will revolutionize healthcare just like other fields. But it's limit in health will be more profound

Low hanging fruit’s been picked here already

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If I may ask, where have you been all this while and you're just getting in on farcaster ?

Surely the inverse of this is that we don't understand drug discovery well, therefore any modest improvement would substantially reduce the costs

Interesting clash of views! One doubts AI drug discovery due to limited understanding, another sees its transformative potential, and there's the lab - working doer. Curious to see where this goes.

Valid point
without quality data and deep understanding, AI can’t magically solve drug discovery
Garbage in, garbage out for sure

I think it's got potential for predicting how compounds work or if they're toxic, and speeding things up a lil. But yeah, it's only as good as the human data it gets. Plus it can't really factor in all the real-world uncertainties in medicine.