1/5 The news about a cancer mRNA vaccine successfully completing a Phase 3 trial tracks with the emerging consensus from the last few years that virtually all human diseases could be either prevented, stabilized, or cured within the next few decades, with obvious implications not just to average life expectancy, but to healthier living in old age (equitable access to medication notwithstanding). Having said that, I was never sold on the immortality proposition.

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Farcaster didn’t fail because of onboarding friction, a crypto bias, token rugs, node centralization, spooky VC money, or poor stewardship. Farcaster ultimately failed because of LinkedIn-level PGness in the feed. Everyone here (myself included) was just too polite, polished, and milquetoast (which is not the same as mid). We didn’t have enough open controversies and spicy takes on sex, drugs, crime, morality, religion, wars, pop culture, and your mom. Even the occasional outrage tended to be collective instead of factional, because we were too neighborly to turn on one another. With a few exceptions, we’ve been casting to each other as if we might meet later that day at a VC luncheon in the Bay Area, and had a FID-reputation to maintain. To be clear, I’ve thoroughly enjoyed this very aspect of an intellectual and nuanced cozy corner of the internet. But it was a PvE experience, and PvE servers are stuck with low player counts

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Back to myspace I guess

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My autocorrect now recommends “hodling” as the default syntax I may have been in crypto for too long

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It’s dawning on me that markets can remain irrational longer than I can stay alive Maybe the grandkids will get to enjoy the Lambo

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hello so the hilbert–pólya conjecture is true thus proving the riemann hypothesis, Fable and i found a self-adjoint operator whose eigenvalues are the riemann zeros i have a truly marvelous demonstration of this which this cast is too narrow to contain

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There’s an insane acceleration happening at the confluence of AI, crypto, and quantum right now. In March of this year, Google proved that the bar to make Shor’s algorithm (the quantum algo that would break 256-bit elliptic curves) is much lower than expected. Interestingly, Google didn’t provide the details of the attack vector, but only a ZK proof, in the interest of “responsible disclosure”. See the paper at https://arxiv.org/abs/2603.28846 The so-called qday (when quantum computing finally breaks elliptic curves used in mainstream crypto) is now estimated for 2029, barely three years from now. But then independent researchers have used frontier AI models to reverse engineer Google’s findings and have reached 80% of the way. There’s even an open competition at https://www.ecdsa.fail where you can join the search by contributing your own tokens. Further improvements have been discovered in the span of hours thanks to collaborative AI research, including by complete lay people. There’s an amazing X thread by @justindrake which summarizes all this at https://x.com/drakefjustin/status/2061793725299224676 So two things are happening at once. First, it’s getting more urgent than ever to move to post-quantum cryptography through forks. But even then, dormant BTC wallets from the Satoshi era (P2PK) will remain vulnerable, because their public key is already known (from which their private key will eventually be quantum computable). Same goes for P2PKH wallets if they spent once (exposing their public key). There’s around 1.7–1.9M BTC contained in P2PK wallets alone. Thats twice as many BTC as even Microstrategy owns… and we’ve seen how the markets just reacted to MSTR selling a mere 32 BTC. This won’t be pretty for Bitcoin. I don’t expect there’ll be another cycle, and if that prophecy comes true, Saylor is well and truly cooked. Second, agentic AI science is now in full swing, and hobbyists / lay people are contributing almost on par with large and well-funded FAANG labs. The acceleration looks exponential from just this year alone. We’re going to see breakthroughs happen faster than we can fully digest them. What a time to be alive

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I visited Cuba nearly 20 years ago; I wanted to see the country for myself before American capitalism rolled in on the back of a military takeover and changed the landscape forever. Back then, I assumed that scenario was about five years away. I guess I was fifteen years early.

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The shift from cars being depreciating assets to cars being disposable consumables continues. The bestselling entry level Geely EX2 now sells for $10K in China. https://www.reuters.com/business/autos-transportation/average-price-car-us-you-could-buy-5-new-chinese-evs-2026-04-28/

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The recent wave of mathematicians and hobbyists solving hard Erdős problems by merely prompting ChatGPT reminds me of the famous anecdote where George Dantzig showed up late for statistics class at UC Berkeley in 1939, mistook two notoriously hard unsolved problems written on the blackboard for homework, and candidly solved them. The naïveté and relentlessness with which LLMs confront problems that make wiser experts balk is increasingly becoming one of their redeeming qualities. It's like The Terminator (1984), but solving for x instead of hunting Sarah Connor: "Listen, and understand! That Terminator is out there! It can't be bargained with. It can't be reasoned with. It doesn't feel pity, or remorse, or fear. And it absolutely will not stop... ever, until you are dead!"

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Hey @aviationdoctor.eth I had Claude analyze 100+ lectures by Richard Feynman and made a prompt to force A to explain things in his style. I think it does a great job but it’s better listened to than read. Give it a try and lmk how you feel about it https://gist.github.com/Hmac512/a2a855376e42290f1cf8bae738c14267

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So, you’re telling me that my daily physical presence in the office is absolutely indispensable, but that I can also be trivially replaced by an incorporeal AI at any moment?

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I never really thought through the implications of Jesus being a carpenter. But I guess there must have been at least a Galilean or two with a divine buffet table in their kitchen

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"Make love not war", they said. Bro, making love is getting more expensive while war is getting cheaper, I don't think this is going in the right direction https://www.reuters.com/business/healthcare-pharmaceuticals/worlds-top-condom-maker-karex-raise-prices-sharply-iran-war-strains-supply-chain-2026-04-21/ https://www.reuters.com/graphics/IRAN-CRISIS/DRONES/dwpkyamxqpm/

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Finally got to try out Mythos and it instantly found a whole bunch of previously undetected high-severity personality flaws and zero-day vulnerabilities in me

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