THANK YOU FOR ALL YOUR SUPPORT IN 2025! I am amazed by the steady growth of this newsletter and how it remains at a open rate of 41.8% (not sure if my personal emails even get read at this %!) I will be on a road trip for the remainder of the year and Reframe Daily will return January 5th Monday. Take care ‘til then! Today in one sentence: Kids given extra nutrition before Hirschsprung surgery had far fewer serious gut infections, Parkinson’s patients improved fitness with breathing-muscle training, one-dose Gardasil 9 stayed strongly immune for years, a sham-controlled trial found brain-stimulation benefits for adult ADHD, and a manganese-boosted probiotic fought colorectal cancer in preclinical tests. https://reframedaily.beehiiv.com/p/reframe-daily-one-nutrition-tweak-cut-kids-post-surgery-gut-infections-from-29-to-7-plus-new-breathi

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Posting from uno web for the first time! Two big eye studies show some eye disease patients can stretch shots to 12–16 weeks, a liver-cancer combo helped tumors shrink after PD-1 failed, and a Chagas vaccine helped protect dogs’ hearts. https://reframedaily.beehiiv.com/p/reframe-daily-new-heart-safety-results-for-tirzepatide-plus-fewer-shots-for-eye-disease-12-16-weeks

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Today in one sentence: A U.S.-available bone drug may also ease knee arthritis, a new weekly diabetes shot beat dulaglutide for weight and blood sugar, a monthly shot sharply cut severe itch, one or two HPV shots still looked strong after 5+ years, and an early new breast-cancer pill shrank some tumors in first human tests. https://reframedaily.beehiiv.com/p/reframe-daily-denosumab-eased-knee-arthritis-pain-and-a-new-weekly-shot-beat-dulaglutide-for-weight

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Today in one sentence: Researchers found clues in stomach fluid that could help catch stomach cancer earlier, showed a possible tweak to improve IVF embryo growth, and reported early-stage lab/animal work toward new antivirals and Alzheimer’s targets. https://reframedaily.beehiiv.com/p/reframe-daily-new-test-in-stomach-fluid-could-spot-stomach-cancer-earlier-plus-ivf-embryos-got-a-boo

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Reframe Daily—curated by Christin Chong (neuroscience PhD, Buddhist chaplain, healthtech strategy consultant)—delivers optimistic and credible health research updates you won’t find in most popular news outlets, from sources scientists and healthcare providers read and trust. Today in one sentence: Doctors tested a new sedation mix that made a tough scope procedure smoother, a kid formula changed gut bugs and helped bone and muscle growth, and a Parkinson’s-linked mouse study cut harmful brain protein clumps—while the FDA okayed two new gonorrhea pills. https://reframedaily.beehiiv.com/p/reframe-daily-fda-just-approved-2-new-gonorrhea-pills-and-a-one-shot-mrna-vaccine-saved-mice-from-a

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Today in one sentence: Researchers sharpened how we use high-dose flu vaccines in seniors, built a small bone-scanner that works without X-rays, showed that movement can “wake up” tired immune cells in damaged lungs, tested video-based training to reduce diagnostic errors, and charted fragile balance cells in the ear to guide future repair therapies. https://reframedaily.beehiiv.com/p/reframe-daily-new-flu-shot-trial-copd-workouts-and-a-no-x-ray-knee-fracture-scanner

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Reframe Daily: New ICU trials test “auto-pilot” breathing, frozen surgery platelets, and gentler care for tiny preemies Today’s studies show automated ventilators that can free ICU patients from machines sooner, frozen platelets that work as well as fresh ones in surgery, safer “wait and see” care for fragile preemie hearts, early steps toward matching sepsis drugs to each patient’s immune system, and a heart medicine that may one day help heal scarred livers. https://reframedaily.beehiiv.com/p/reframe-daily-new-icu-trials-test-auto-pilot-breathing-frozen-surgery-platelets-and-gentler-care-for

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Today in one sentence: The FDA cleared the first cell therapy for severe aplastic anemia; a one-time gene treatment into the spinal fluid helped children with spinal muscular atrophy in a big trial; a new flu shot boosted both antibodies and T cells; a daily pill for narcolepsy sharpened thinking; a combo drug plan after liver cancer surgery looked safe enough for larger tests; and home brain-stimulation for people with Alzheimer’s improved memory and daily tasks. https://reframedaily.beehiiv.com/p/reframe-daily-fda-approves-first-cell-therapy-for-severe-aplastic-anemia-plus-big-wins-in-gene-and-b

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Reframe Daily: New eye cancer cream, cooler prostate surgery, lab-grown liver repair (and happy thanksgiving!) In small studies, a cream helped clear eye-surface tumors, cooling the nerves during prostate surgery protected erections and bladder control, ICU drugs may help patients get off breathing machines faster, and lab work in rats and mice points to new ways to heal fatty and damaged livers. https://reframedaily.beehiiv.com/p/reframe-daily-new-eye-cancer-cream-cooler-prostate-surgery-lab-grown-liver-repair-and-happy-thanksgi

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Reframe Daily: Old diabetes pill still works, new cancer vaccines, and a parasite shot in early tests Metformin helps adults with type 1 diabetes use less insulin, early vaccines are targeting a rare liver cancer and schistosomiasis, an off-the-shelf CAR-T treatment is shrinking myeloma, and brain immune cells are opening a fresh path to slow early Alzheimer’s. https://reframedaily.beehiiv.com/p/reframe-daily-old-diabetes-pill-still-works-new-cancer-vaccines-and-a-parasite-shot-in-early-tests

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HIV switch that helps bones, safer pneumonia antibiotic, and tougher tooth fillings An earlier switch to a newer HIV pill helped hip bones get stronger, a newer pneumonia drug worked well in older adults, back-tooth fillings stayed solid for years, adding a common steroid made vein surgery less painful, and a simple blood test may help coaches set safer hard workouts. https://reframedaily.beehiiv.com/p/reframe-daily-hiv-switch-that-helps-bones-safer-pneumonia-antibiotic-and-tougher-tooth-fillings

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Today’s reframe Summary This study examined how delivering a combination of interventions—from before conception through early childhood—affects anemia in young children. The interventions included nutrition support, healthcare, WASH (water, sanitation, and hygiene), and psychosocial care. Using a randomized controlled trial, researchers compared children who received these interventions during preconception, pregnancy, and early childhood with those who received routine care. At 24 months of age, children in the intervention groups had significantly lower rates of mild, moderate, and severe anemia. Overall, the findings show that providing an integrated package of health, nutrition, and hygiene interventions throughout early life dramatically reduces childhood anemia. These interventions can be implemented through existing government programs, especially in South Asian countries where anemia rates are high.

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Today in one sentence: A long-term health program starting before birth sharply cut anemia in young children, a modified mRNA flu shot worked well in a big human trial, a one-time gene therapy greatly lowered bleeding in people with hemophilia B, gentle brain stimulation shifted reward signals in kids with ADHD, and a new MRI method estimated liver tumor cell size so well it could one day guide care with fewer needle biopsies. Read more and subscribe with the link (or tap the big yellow sign) https://reframedaily.beehiiv.com/p/reframe-daily-new-mrna-flu-shot-one-time-hemophilia-fix-and-virtual-biopsies-for-liver-tumors

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Summary of todays reframe; <> Reducing maternal infections: Simple, low-cost infection prevention steps in hospitals across Malawi and Uganda cut life-threatening maternal infections and deaths by about 33%. <> Powerful cancer-killing T cells discovered: Scientists identified strong CD8 T-cell clusters from melanoma tumors that were more effective in shrinking cancer in mice than typical T-cell mixtures. <> Understanding liver cancer origins: Researchers traced how liver cells turn cancerous when beta-catenin mutates and found that blocking the IGFBP2–mTOR pathway can stop early tumor growth in mice. <> Fixing stop-signal gene mutations: A new method combining prime editing with engineered suppressor tRNAs successfully repaired faulty proteins in mouse cells, offering promise for treating nonsense-mutation disorders. <> AI creates working genes from scratch: A genomic AI model was able to generate brand-new, functional genes that worked on the first attempt in cells—paving the way for breakthroughs in enzymes, vaccines, and gene therapy.

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today’s reframe daily: • Fish oil (rich in EPA) helped calm inflammation and keep blood sugar steadier in people with serious burns in a randomized clinical trial. • An early‑care program for first‑episode psychosis cut the chance of developing schizophrenia by ~39% over 2 years versus usual care in a randomized trial. • A vaginal‑spray probiotic (Bacillus spores) added to standard care improved symptoms and reduced harmful bacteria for bacterial vaginosis in a double‑blind, randomized pilot study. • In mice with autoimmune type 1 diabetes, a chemo‑free antibody conditioning plus blood‑ and islet‑cell transplants restored immune tolerance and reversed diabetes without chronic immunosuppression.

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