@xuyamu

@xuyamu It is a simple logic: the short lifespan of a mouse is inevitably restricted by its own inherent "bottlenecks." If a longevity-enhancing method produces similar, marginal effects across different species, it clearly isn't the deciding factor for lifespan. The truly critical factors must be those that vary drastically from one species to another. Rapamycin, for instance, provides a similar and relatively weak extension of life across various species, suggesting it isn't the key to a radical lifespan breakthrough. In contrast, DNA repair capabilities differ immensely between long-lived and short-lived species. A naked mole rat can live for 30 years, a human for 120, and a bowhead whale for 200. Even if you use Rapamycin to extend a mouse's life by 15%, so what? The mouse still won't come anywhere near the natural lifespan of a naked mole rat.

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