steambeer.eth (steambeer)

Here's a exciting new preprint on the generative design of peptides to disrupt protein–protein interactions. Anyone with expertise can submit a public peer review on ResearchHub and earn $150 in RSC (now on Coinbase!). Review bounty: https://www.researchhub.com/paper/9460598/generative-design-of-high-affinity-peptides-using-bindcraft/bounties

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Just published a new @researchhub Journal paper on how different DNA polymerase peptides compete for the Mycobacterial β‑clamp. X‑ray crystal structures plus binding assays reveal how clamp‑binding motifs drive polymerase recruitment.

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I used Biomni Co-Pilot to fit data for the first time (until today I've only used it for construct design and background research). I was super impressed. It was simple peptide binding data, but it did the fitting, made the plots, and gave me a nice text summary in less than 5 minutes. I do this type of analysis all the time and it would have probably taken me 15 minutes if I didn't get interrupted by anything. If you are interested, you can see the output at the very bottom of this research notebook: I'm looking forward to giving it more complex data soon.

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https://www.researchhub.com/paper/9446281/structural-basis-for-differential-affinity-and-competitive-binding-of-dna-polymerase-peptides-to-the-mycobacterial-clamp

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